Human small cell lung cancer cells express functional VEGF receptors, VEGFR-2 and VEGFR-3
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چکیده
منابع مشابه
Modulation of VEGFR-2-mediated endothelial-cell activity by VEGF-C/VEGFR-3.
Vascular endothelial growth factor (VEGF) receptor 3 (VEGFR-3), a receptor for VEGF-C, was shown to be essential for angiogenesis as well as for lymphangiogenesis. Targeted disruption of the VEGFR-3 gene in mice and our previous study using an antagonistic monoclonal antibody (MoAb) for VEGFR-3 suggested that VEGF-C/VEGFR-3 signals might be involved in the maintenance of vascular integrity. In ...
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BACKGROUND Colorectal cancer (CRC) is the third most common type of cancer and the fourth most frequent cause of cancer death. Literature indicates that vascular endothelial growth factor is a predominant angiogenic factor and that angiogenesis plays an important role in the progression of CRC. PATIENTS AND METHODS The present series consisted of tissue samples obtained from 672 patients who ...
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Vascular endothelial growth factor A (VEGF) acts via two vascular endothelial growth factor receptors VEGFR-1 and VEGFR-2 that play important and distinct roles in tumor biology. We reasoned that selective imaging of these receptors could provide unique information for diagnostics and for monitoring and optimizing responses to anti-cancer therapy, including antiangiogenic therapy. Herein, we re...
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............................................................................................................................ 6 REVIEW OF THE LITERATURE...................................................................................... 7 1. THE BLOOD VASCULAR SYSTEM........................................................................... 7 Development of the blood vessels......................
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ژورنال
عنوان ژورنال: Lung Cancer
سال: 2004
ISSN: 0169-5002
DOI: 10.1016/j.lungcan.2004.03.006